10 20 30 40 50
UGAUUACUCAAUUAUAG-----| AAG U GUCGUUC UA
AUUGU GG CCAGGUGGGGUGCAUAUU C
UAACA CC GGUCCGCCCCACGUAUAA C
AUCUCACCUACAGCUUGUCAAC^ A-- - GUGAU- U AA
110 100 90 80 70 60
It is not clear either from phylogenetic or syntenic information how many Mir-92 genes were present in the last common ancestor of bilaterians and how the vertebrate Mir-92s relate to the invertebrate Mir-92s and thus these multiple paralogues in invertebrates are classified here as orphans pending new data.