Let-7-P2b3a

MirGeneDB ID

Gmo-Let-7-P2b3a

Family name

LET-7 (all species)

Species

Cod (Gadus morhua)

MiRBase ID

gmo-let-7h-1

Paralogues

Gmo-Let-7-P1b1 Gmo-Let-7-P1b2 Gmo-Let-7-P1c2 Gmo-Let-7-P1d1 Gmo-Let-7-P1d2 Gmo-Let-7-P2a1a Gmo-Let-7-P2a2a Gmo-Let-7-P2a3a Gmo-Let-7-P2a3b Gmo-Let-7-P2a4a Gmo-Let-7-P2a4b Gmo-Let-7-P2b1a Gmo-Let-7-P2b2a Gmo-Let-7-P2b3b Gmo-Let-7-P2b4a Gmo-Let-7-P2b4b Gmo-Let-7-P2c2a Gmo-Let-7-P2c2b Gmo-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2b3 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2b3 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2b3 Cfa-Let-7-P2b3 Cja-Let-7-P2b3 Cpi-Let-7-P2b3 Cpo-Let-7-P2b3 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2b3 Dpu-Let-7 Dre-Let-7-P2b3a Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2b3 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2b3 Gja-Let-7-P2b3 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Hsa-Let-7-P2b3 Isc-Let-7 Laf-Let-7-P2b3 Lan-Let-7 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2b3 Mal-Let-7-P2b3a Mgi-Let-7 Mml-Let-7-P2b3 Mmr-Let-7-P2b3 Mmu-Let-7-P2b3 Mom-Let-7 Mun-Let-7-P2b3 Npo-Let-7 Oan-Let-7-P2b3 Obi-Let-7 Ocu-Let-7-P2b3 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2b3 Pau-Let-7 Pbv-Let-7-P2b3 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2b3 Rph-Let-7 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2b3 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2b3 Tca-Let-7 Tni-Let-7-P2b3a Tni-Let-7-P2b3b Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P2b3c Xla-Let-7-P2b3d Xtr-Let-7-P2b3

Node of Origin (locus)

Clupeocephala

Node of Origin (family)

Bilateria

Genome context
(Gadus_morhua.gadMor1.dna.toplevel)

GeneScaffold_2603: 770560-770640 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2b3a)

Let-7-P2a3a GeneScaffold_2603: 770245-770315 [+] UCSC Ensembl
Let-7-P2b3a GeneScaffold_2603: 770560-770640 [+] UCSC Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

UAUUAAUGUCCGAAUCUGGCUAUGCUGUGGUGAGGUAGUAAGUUGUGUUGUUGUUGGGGAUCAGGAUUAUUCACCCCGUUCAGGAGAUAACUAUACAACUUACUGCCUUCCUCAGUGUAGGCCCUGAACAUCAUGGUGGUG

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Structure

        10          20        30        40        50        60        70
UAUUAAUGUCCGAAUCU-  -|       U  U                 U   GUUGGGGAUCAGGAUUA 
                  GG CUAUGCUG GG GAGGUAGUAAGUUGUGU GUU                 U
                  CC GAUGUGAC CC UUCCGUCAUUCAACAUA CAA                 U
GUGGUGGUACUACAAGUC  G^       U  -                 U   UAGAGGACUUGCCCCAC 
 .       130       120       110        100        90        80

Deep sequencing

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Comment

Although there is a templated T at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' U is supported by the conservation of Let7-P2 processing.

3' NTU

Yes

Motifs

UG at 5p(-14), CNNC at 3p(+17)

Tissue expression

Br	Gi	He	In	Li	Sk	Sp	Wh

Mature sequence

Gmo-Let-7-P2b3a_5p

mirBase accession

MIMAT0044165

Sequence

0- UGAGGUAGUAAGUUGUGUUGUU -22

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Star sequence

Gmo-Let-7-P2b3a_3p*

mirBase accession

MIMAT0044202

Sequence

60- CUAUACAACUUACUGCCUUCC -81

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