Mir-10-P2b

MirGeneDB ID

Xtr-Mir-10-P2b

Family name

MIR-10 (all species)

Seed

ACCCGUA

Species

Tropical clawed frog (Xenopus tropicalis)

MiRBase ID

xtr-mir-100

Paralogues

Xtr-Mir-10-P1b-v1 Xtr-Mir-10-P1b-v2 Xtr-Mir-10-P1c-v1 Xtr-Mir-10-P1c-v2 Xtr-Mir-10-P1d-v1 Xtr-Mir-10-P1d-v2 Xtr-Mir-10-P2c Xtr-Mir-10-P3b Xtr-Mir-10-P3c Xtr-Mir-10-P3d

Orthologues

Aae-Mir-10-P2 Aca-Mir-10-P2b Ami-Mir-10-P2b Bfl-Mir-10-P2-v1 Bfl-Mir-10-P2-v2 Bge-Mir-10-P2 Bla-Mir-10-P2-v1 Bla-Mir-10-P2-v2 Bpl-Mir-10-P2 Bta-Mir-10-P2b Cbr-Mir-10-P2 Cel-Mir-10-P2 Cfa-Mir-10-P2b Cgi-Mir-10-P2 Cin-Mir-10-P2 Cpi-Mir-10-P2b Cpo-Mir-10-P2b Cte-Mir-10-P2 Dan-Mir-10-P2 Dma-Mir-10-P2 Dme-Mir-10-P2 Dmo-Mir-10-P2 Dpu-Mir-10-P2 Dsi-Mir-10-P2 Dya-Mir-10-P2 Ete-Mir-10-P2b Gja-Mir-10-P2b Hsa-Mir-10-P2b Isc-Mir-10-P2 Lan-Mir-10-P2 Lch-Mir-10-P2b Lgi-Mir-10-P2 Mml-Mir-10-P2b Mmu-Mir-10-P2b Mun-Mir-10-P2b Npo-Mir-10-P2 Nve-Mir-10 Oan-Mir-10-P2b Obi-Mir-10-P2 Ocu-Mir-10-P2b Ovu-Mir-10-P2 Pbv-Mir-10-P2b Pfl-Mir-10-P2 Pmi-Mir-10-P2 Rno-Mir-10-P2b Sha-Mir-10-P2b Sko-Mir-10-P2 Spt-Mir-10-P2b Sto-Mir-10-P2b Tca-Mir-10-P2 Xbo-Mir-10-P2 Xbo-Mir-10-P2-as Xla-Mir-10-P2b1 Xla-Mir-10-P2b2

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Eumetazoa

Genome context
(xenTro9_add)

chr7: 112711722-112711779 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-10-P2b)

Mir-10-P2b chr7: 112711722-112711779 [+] UCSC Ensembl
Let-7-P1b chr7: 112714578-112714644 [+] UCSC Ensembl
Mir-10-P3b chr7: 112726416-112726474 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

UGUAUUGUACAUGUAUUGCUGGUUGCCAUAAACCCGUAGAUCCGAACUUGUGCUGUGCCCCUCUCACAAGCUCGAGUGUGCGGGUCUGUGUCGGCUUGGCUACGGCGGCGUGAGUGAG

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Structure

        10         20         30        40        50        
UGUAUUGUACAUGUAUU-   -|    C    A       G UC   A      CUGUG 
                  GCU GGUUG CAUA ACCCGUA A  CGA CUUGUG     C
                  CGG UCGGC GUGU UGGGCGU U  GCU GAACAC     C
GAGUGAGUGCGGCGGCAU   U^    U    C       G GA   C      UCUCC 
      110       100        90        80        70        60

Deep sequencing

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Comment

Based on the 3' moR reads in human (P2b) and platypus (P2c) it appears that this is a Group 2 miRNA.

3' NTU

Yes

Motifs

UG at 5p(-14), CNNC at 3p(+17)

Tissue expression

Br	Em	Em	Em	Em	He

Mature sequence

Xtr-Mir-10-P2b_5p

mirBase accession

MIMAT0003682

Sequence

0- AACCCGUAGAUCCGAACUUGUG -22

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Proposed targets

TargetScanVert: xtr-miR-100

Star sequence

Xtr-Mir-10-P2b_3p*

mirBase accession

None

Sequence

36- CAAGCUCGAGUGUGCGGGUCUG -58

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