Mir-10-P2b

MirGeneDB ID

Hsa-Mir-10-P2b

Family name

MIR-10 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-mir-99b

Paralogues

Hsa-Mir-10-P1b-v1 Hsa-Mir-10-P1c-v1 Hsa-Mir-10-P2c Hsa-Mir-10-P2d Hsa-Mir-10-P3b Hsa-Mir-10-P3c Hsa-Mir-10-P3d

Orthologues

Aae-Mir-10-P2 Aca-Mir-10-P2b Adi-Mir-10 Aga-Mir-10-P2 Agr-Mir-10-P2 Ami-Mir-10-P2b Asp-Mir-10 Bfl-Mir-10-P2-v1 Bge-Mir-10-P2 Bko-Mir-10-P2 Bla-Mir-10-P2-v1 Bpl-Mir-10-P2 Bta-Mir-10-P2b Cbr-Mir-10-P2 Cel-Mir-10-P2 Cfa-Mir-10-P2b Cin-Mir-10-P2 Cja-Mir-10-P2b Cpi-Mir-10-P2b Cpo-Mir-10-P2b Cte-Mir-10-P2 Dan-Mir-10-P2 Dgr-Mir-10-P2 Dlo-Mir-10-P2 Dma-Mir-10-P2 Dme-Mir-10-P2 Dmo-Mir-10-P2 Dpu-Mir-10-P2 Dsi-Mir-10-P2 Dya-Mir-10-P2 Eba-Mir-10-P2 Eca-Mir-10-P2b Ete-Mir-10-P2b Gja-Mir-10-P2b Gpa-Mir-10-P2 Gsp-Mir-10-P2 Hru-Mir-10-P2 Isc-Mir-10-P2 Laf-Mir-10-P2b Lan-Mir-10-P2 Lch-Mir-10-P2b Lgi-Mir-10-P2 Lhy-Mir-10-P2 Llo-Mir-10-P2 Mgi-Mir-10-P2 Mml-Mir-10-P2b Mmr-Mir-10-P2b Mmu-Mir-10-P2b Mom-Mir-10-P2 Mun-Mir-10-P2b Neu-Mir-10-P2b Npo-Mir-10-P2 Nve-Mir-10 Oan-Mir-10-P2b Obi-Mir-10-P2 Ocu-Mir-10-P2b Ofu-Mir-10-P2 Ovu-Mir-10-P2 Pab-Mir-10-P2b Pau-Mir-10-P2 Pbv-Mir-10-P2b Pca-Mir-10-P2 Pdu-Mir-10-P2 Pfl-Mir-10-P2 Ple-Mir-10-P2 Pmi-Mir-10-P2 Pve-Mir-10-P2 Rno-Mir-10-P2b Rph-Mir-10-P2 Sha-Mir-10-P2b Sko-Mir-10-P2 Snu-Mir-10-P2 Spt-Mir-10-P2b Sto-Mir-10-P2b Tca-Mir-10-P2 Tur-Mir-10-P2 Xbo-Mir-10-P2 Xbo-Mir-10-P2-as Xla-Mir-10-P2b1 Xla-Mir-10-P2b2 Xtr-Mir-10-P2b

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Eumetazoa

Genome context
(hg38)

chr19: 51692618-51692677 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-10-P2b)

Mir-10-P2b chr19: 51692618-51692677 [+] UCSC Ensembl
Let-7-P1b chr19: 51692793-51692859 [+] UCSC Ensembl
Mir-10-P3b chr19: 51693268-51693327 [+] UCSC Ensembl

Seed

ACCCGUA

Precursor
(pre-Mir +30nt flank)

CGGGGGCCCGGACUCCUGGGUCCUGGCACCCACCCGUAGAACCGACCUUGCGGGGCCUUCGCCGCACACAAGCUCGUGUCUGUGGGUCCGUGUCGGGGGCUCACCAUCGCGGCUGGGGCC

Get precursor sequence

Structure

        10         20         30        40        50         
CGGGGGCCCGGACUCCU-   -|        CC         AC   C    CGGGGCCU 
                  GGG UCCUGGCAC  ACCCGUAGA  CGA CUUG        U
                  CUC GGGGCUGUG  UGGGUGUCU  GCU GAAC        C
CCGGGGUCGGCGCUACCA   G^        CC         GU   C    ACACGCCG 
.       110       100        90        80        70        60

Deep sequencing

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Comment

Based on the 3' DcRNA reads in human (P2b) and platypus (P2c) it appears that this is a Group 2 miRNA.

3' NTU

Yes

Motifs

UG at 5p(-14)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Mir-10-P2b_5p

mirBase accession

MIMAT0000689

Sequence

0- CACCCGUAGAACCGACCUUGCG -22

Get sequence

Proposed targets

microrna.org: MIMAT0000689
TargetScanVert: hsa-miR-99b-5p
TargetMiner: hsa-miR-99b-5p
miRDB: MIMAT0000689

Star sequence

Hsa-Mir-10-P2b_3p*

mirBase accession

MIMAT0004678

Sequence

38- CAAGCUCGUGUCUGUGGGUCCG -60

Get sequence

Proposed targets

microrna.org: MIMAT0004678
TargetScanVert: hsa-miR-99b-3p
TargetMiner: hsa-miR-99b-3p
miRDB: MIMAT0004678