Mir-10-P2c

MirGeneDB ID

Hsa-Mir-10-P2c

Family name

MIR-10 (all species)

Seed

ACCCGUA

Species

Human (Homo sapiens)

MiRBase ID

hsa-mir-99a

Paralogues

Hsa-Mir-10-P1b-v1 Hsa-Mir-10-P1b-v2 Hsa-Mir-10-P1c-v1 Hsa-Mir-10-P1c-v2 Hsa-Mir-10-P2b Hsa-Mir-10-P2d Hsa-Mir-10-P3b Hsa-Mir-10-P3c Hsa-Mir-10-P3d

Orthologues

Aae-Mir-10-P2 Aca-Mir-10-P2c Ami-Mir-10-P2c Bfl-Mir-10-P2-v1 Bfl-Mir-10-P2-v2 Bge-Mir-10-P2 Bla-Mir-10-P2-v1 Bla-Mir-10-P2-v2 Bpl-Mir-10-P2 Bta-Mir-10-P2c Cbr-Mir-10-P2 Cel-Mir-10-P2 Cfa-Mir-10-P2c Cgi-Mir-10-P2 Cin-Mir-10-P2 Cli-Mir-10-P2c Cmi-Mir-10-P2c Cpi-Mir-10-P2c Cpo-Mir-10-P2c Cte-Mir-10-P2 Dan-Mir-10-P2 Dma-Mir-10-P2 Dme-Mir-10-P2 Dmo-Mir-10-P2 Dno-Mir-10-P2c Dpu-Mir-10-P2 Dre-Mir-10-P2c1 Dre-Mir-10-P2c2 Dsi-Mir-10-P2 Dya-Mir-10-P2 Ete-Mir-10-P2c Gga-Mir-10-P2c Gja-Mir-10-P2c Gmo-Mir-10-P2c2 Isc-Mir-10-P2 Lan-Mir-10-P2 Lch-Mir-10-P2c Lgi-Mir-10-P2 Loc-Mir-10-P2c Mal-Mir-10-P2c2 Mml-Mir-10-P2c Mmu-Mir-10-P2c Mun-Mir-10-P2c Npo-Mir-10-P2 Nve-Mir-10 Oan-Mir-10-P2c Obi-Mir-10-P2 Ocu-Mir-10-P2c Ovu-Mir-10-P2 Pbv-Mir-10-P2c Pfl-Mir-10-P2 Pmi-Mir-10-P2 Rno-Mir-10-P2c Sha-Mir-10-P2c Sko-Mir-10-P2 Spt-Mir-10-P2c Sto-Mir-10-P2c Tca-Mir-10-P2 Tgu-Mir-10-P2c Xbo-Mir-10-P2 Xbo-Mir-10-P2-as Xla-Mir-10-P2c3 Xla-Mir-10-P2c4 Xtr-Mir-10-P2c

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Eumetazoa

Genome context
(hg38)

chr21: 16539101-16539159 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-10-P2c)

Mir-10-P2c chr21: 16539101-16539159 [+] UCSC Ensembl
Let-7-P1c chr21: 16539838-16539904 [+] UCSC Ensembl

Precursor
(pre-Mir +30nt flank)

GGCCCAUGCAAGAUGUUGCCCAUUGGCAUAAACCCGUAGAUCCGAUCUUGUGGUGAAGUGGACCGCACAAGCUCGCUUCUAUGGGUCUGUGUCAGUGUGGUAAUCUGACAAAAUGCUAU

Get precursor sequence

Structure

        10         20         30        40        50         
GGCCCAUGCAAGAUGUU-   -|         A         UC   U      GUGAAG 
                  GCC CAUUGGCAUA ACCCGUAGA  CGA CUUGUG      \
                  UGG GUGACUGUGU UGGGUAUCU  GCU GAACAC      U
UAUCGUAAAACAGUCUAA   U^         C         UC   C      GCCAGG 
       110       100        90        80        70        60

Deep sequencing

Go to detailed chart

Comment

Based on the 3' moR reads in human (P2b) and platypus (P2c) it appears that this is a Group 2 miRNA.

3' NTU

Yes

Motifs

UG at 5p(-14), UGUG in loop

Tissue expression

Ad	Ar	Bl	Bo	Bo	Bo	Bo	Bo	Br	Br	Br	Br	Br	Br	Br	Br	Br	Br	Br	Es	Ga	He	He	He	He	He	Ki	Li	Lu	Ly	Mu	Ne	Pa	Pl	Pl	Sk	Sp	Sp	St	Su	Te	Th	To	Tr	Ve

Mature sequence

Hsa-Mir-10-P2c_5p

mirBase accession

MIMAT0000097

Sequence

0- AACCCGUAGAUCCGAUCUUGUG -22

Get sequence

Proposed targets

microrna.org: MIMAT0000097
TargetScanVert: hsa-miR-99a-5p
TargetMiner: hsa-miR-99a-5p
miRDB: MIMAT0000097

Star sequence

Hsa-Mir-10-P2c_3p*

mirBase accession

MIMAT0004511

Sequence

37- CAAGCUCGCUUCUAUGGGUCUG -59

Get sequence

Proposed targets

microrna.org: MIMAT0004511
TargetScanVert: hsa-miR-99a-3p
TargetMiner: hsa-miR-99a-3p
miRDB: MIMAT0004511