Mir-10-P2c

MirGeneDB ID

Mmu-Mir-10-P2c

Family name

MIR-10 (all species)

Species

House mouse (Mus musculus)

MiRBase ID

mmu-mir-99a

Paralogues

Mmu-Mir-10-P1b-v1 Mmu-Mir-10-P1c-v1 Mmu-Mir-10-P2b Mmu-Mir-10-P2d Mmu-Mir-10-P3b Mmu-Mir-10-P3c Mmu-Mir-10-P3d

Orthologues

Aae-Mir-10-P2 Aca-Mir-10-P2c Adi-Mir-10 Aga-Mir-10-P2 Agr-Mir-10-P2 Ami-Mir-10-P2c Asp-Mir-10 Bfl-Mir-10-P2-v1 Bge-Mir-10-P2 Bko-Mir-10-P2 Bla-Mir-10-P2-v1 Bpl-Mir-10-P2 Bta-Mir-10-P2c Cbr-Mir-10-P2 Cel-Mir-10-P2 Cfa-Mir-10-P2c Cin-Mir-10-P2 Cja-Mir-10-P2c Cli-Mir-10-P2c Cmi-Mir-10-P2c Cpi-Mir-10-P2c Cpo-Mir-10-P2c Cte-Mir-10-P2 Dan-Mir-10-P2 Dgr-Mir-10-P2 Dlo-Mir-10-P2 Dma-Mir-10-P2 Dme-Mir-10-P2 Dmo-Mir-10-P2 Dno-Mir-10-P2c Dpu-Mir-10-P2 Dre-Mir-10-P2c1 Dre-Mir-10-P2c2 Dsi-Mir-10-P2 Dya-Mir-10-P2 Eba-Mir-10-P2 Eca-Mir-10-P2c Ete-Mir-10-P2c Gga-Mir-10-P2c Gja-Mir-10-P2c Gmo-Mir-10-P2c2 Gpa-Mir-10-P2 Gsp-Mir-10-P2 Hru-Mir-10-P2 Hsa-Mir-10-P2c Isc-Mir-10-P2 Laf-Mir-10-P2c Lan-Mir-10-P2 Lch-Mir-10-P2c Lgi-Mir-10-P2 Lhy-Mir-10-P2 Llo-Mir-10-P2 Loc-Mir-10-P2c Mal-Mir-10-P2c2 Mgi-Mir-10-P2 Mml-Mir-10-P2c Mmr-Mir-10-P2c Mom-Mir-10-P2 Mun-Mir-10-P2c Neu-Mir-10-P2c Npo-Mir-10-P2 Nve-Mir-10 Oan-Mir-10-P2c Obi-Mir-10-P2 Ocu-Mir-10-P2c Ofu-Mir-10-P2 Ovu-Mir-10-P2 Pab-Mir-10-P2c Pau-Mir-10-P2 Pbv-Mir-10-P2c Pca-Mir-10-P2 Pdu-Mir-10-P2 Pfl-Mir-10-P2 Ple-Mir-10-P2 Pmi-Mir-10-P2 Pve-Mir-10-P2 Rno-Mir-10-P2c Rph-Mir-10-P2 Sha-Mir-10-P2c Sko-Mir-10-P2 Snu-Mir-10-P2 Spt-Mir-10-P2c Sto-Mir-10-P2c Tca-Mir-10-P2 Tgu-Mir-10-P2c Tur-Mir-10-P2 Xbo-Mir-10-P2 Xbo-Mir-10-P2-as Xla-Mir-10-P2c3 Xla-Mir-10-P2c4 Xtr-Mir-10-P2c

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Eumetazoa

Genome context
(mm10)

chr16: 77598940-77598998 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-10-P2c)

Mir-10-P2c chr16: 77598940-77598998 [+] UCSC Ensembl
Let-7-P1c chr16: 77599672-77599738 [+] UCSC Ensembl
Mir-10-P3c chr16: 77646279-77646339 [+] UCSC Ensembl

Seed

ACCCGUA

Precursor
(pre-Mir +30nt flank)

GGUCCCUGUGAGACGAUGCCCAUUGACAUAAACCCGUAGAUCCGAUCUUGUGGUGAAGUGGACCGCGCAAGCUCGUUUCUAUGGGUCUGUGGCAGUGUGGUGAUCUGACAAAGCACUAU

Get precursor sequence

Structure

        10         20         30        40        50         
GGUCCCUGUGAGACGAU-   -|    A    A         UC   U      GUGAAG 
                  GCC CAUUG CAUA ACCCGUAGA  CGA CUUGUG      \
                  UGG GUGAC GUGU UGGGUAUCU  GCU GAACGC      U
UAUCACGAAACAGUCUAG   U^    G    C         UU   C      GCCAGG 
       110       100        90        80        70        60

Deep sequencing

Go to detailed chart

Comment

Based on the 3' DcRNA reads in human (P2b) and platypus (P2c) it appears that this is a Group 2 miRNA.

3' NTU

Yes

Motifs

UG at 5p(-14), UGUG in loop

Tissue expression

Br	Br	Ce	Ce	Em	Em	He	Ki	Li	Lu	Ov	Pa	Sk	Sp	Te

Mature sequence

Mmu-Mir-10-P2c_5p

mirBase accession

MIMAT0000131

Sequence

0- AACCCGUAGAUCCGAUCUUGUG -22

Get sequence

Proposed targets

microrna.org: MIMAT0000131
TargetScanVert: mmu-miR-99a-5p
miRDB: MIMAT0000131

Star sequence

Mmu-Mir-10-P2c_3p*

mirBase accession

MIMAT0016981

Sequence

37- CAAGCUCGUUUCUAUGGGUCUG -59

Get sequence

Proposed targets

TargetScanVert: mmu-miR-99a-3p
miRDB: MIMAT0016981