Let-7-P1d

MirGeneDB ID

Hsa-Let-7-P1d

Family name

LET-7 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7a-2

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1c Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P1d Aga-Let-7 Agr-Let-7 Ami-Let-7-P1d Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P1d Cfa-Let-7-P1d Cin-Let-7-P1 Cja-Let-7-P1d Cli-Let-7-P1d Cmi-Let-7-P1d Cpi-Let-7-P1d Cpo-Let-7-P1d Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P1d Dpu-Let-7 Dre-Let-7-P1d1 Dre-Let-7-P1d2 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P1d Egr-Let-7 Esc-Let-7 Ete-Let-7-P1d Gga-Let-7-P1d Gja-Let-7-P1d Gmo-Let-7-P1d1 Gmo-Let-7-P1d2 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P1d Lan-Let-7 Lch-Let-7-P1d Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P1d Mal-Let-7-P1d1 Mal-Let-7-P1d2 Mdo-Let-7-P1d Mgi-Let-7 Mml-Let-7-P1d Mmr-Let-7-P1d Mmu-Let-7-P1d Mom-Let-7 Mun-Let-7-P1d Neu-Let-7-P1d Npo-Let-7 Oan-Let-7-P1d Obi-Let-7 Ocu-Let-7-P1d Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P1d Pau-Let-7 Pbv-Let-7-P1d Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P1d Rph-Let-7 Sha-Let-7-P1d Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P1d Spu-Let-7 Sro-Let-7 Sto-Let-7-P1d Tca-Let-7 Tgu-Let-7-P1d Tni-Let-7-P1d1 Tni-Let-7-P1d2 Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr11: 122146523-122146589 [-] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P1d)

Mir-10-P3d chr11: 122099769-122099830 [-] UCSC Ensembl
Let-7-P1d chr11: 122146523-122146589 [-] UCSC Ensembl
Mir-10-P2d chr11: 122152240-122152296 [-] UCSC Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

UCCAGCCAUUGUGACUGCAUGCUCCCAGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCUUGGGUCUUGCACUAAACAACAUGGUGAGA

Get precursor sequence

Structure

        10        20           30        40        50        60   
UCCAGCCAUUGUGACUGCA   U---|     UU   G   U             UAGAAUUACA 
                   UGC    CCCAGG  GAG UAG AGGUUGUAUAGUU          \
                   ACG    GGGUUC  UUC AUC UCCGACAUGUCAA          U
AGAGUGGUACAACAAAUC-   UUCU^     CU   G   C             UAGAGGGAAC 
     120       110        100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P1d_5p

mirBase accession

MIMAT0000062

Sequence

0- UGAGGUAGUAGGUUGUAUAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000062
TargetScanVert: hsa-let-7a-5p
TargetMiner: hsa-let-7a-5p
miRDB: MIMAT0000062

Star sequence

Hsa-Let-7-P1d_3p*

mirBase accession

MIMAT0010195

Sequence

45- CUGUACAGCCUCCUAGCUUUCC -67

Get sequence

Proposed targets

microrna.org: MIMAT0010195
TargetScanVert: hsa-let-7a-2-3p
TargetMiner: hsa-let-7a-2-3p
miRDB: MIMAT0010195