Let-7-P2c3

MirGeneDB ID

Hsa-Let-7-P2c3

Family name

LET-7 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7g

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1c Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2

Orthologues

Aae-Let-7 Aca-Let-7-P2c3 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2c3 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2c3 Cfa-Let-7-P2c3 Cja-Let-7-P2c3 Cli-Let-7-P2c3 Cmi-Let-7-P2c3 Cpi-Let-7-P2c3 Cpo-Let-7-P2c3 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2c3 Dpu-Let-7 Dre-Let-7-P2c3 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2c3 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2c3 Gga-Let-7-P2c3 Gja-Let-7-P2c3 Gmo-Let-7-P2c3 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P2c3 Lan-Let-7 Lch-Let-7-P2c3 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2c3 Mal-Let-7-P2c3 Mdo-Let-7-P2c3 Mgi-Let-7 Mml-Let-7-P2c3 Mmr-Let-7-P2c3 Mmu-Let-7-P2c3 Mom-Let-7 Mun-Let-7-P2c3 Npo-Let-7 Oan-Let-7-P2c3 Obi-Let-7 Ocu-Let-7-P2c3 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2c3 Pau-Let-7 Pbv-Let-7-P2c3 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2c3 Rph-Let-7 Sha-Let-7-P2c3 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2c3 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2c3 Tca-Let-7 Tgu-Let-7-P2c3 Tni-Let-7-P2c3 Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P2c3c Xla-Let-7-P2c3d Xtr-Let-7-P2c3

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr3: 52268280-52268357 [-] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2c3)

Let-7-P2c3 chr3: 52268280-52268357 [-] UCSC Ensembl
Mir-135-P1 chr3: 52294233-52294292 [-] UCSC Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

CGCUCCGUUUCCUUUUGCCUGAUUCCAGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCAGGAACAGCGCGCCAGCUGCCAAGUGGGG

Get precursor sequence

Structure

        10           20        30        40        50        60         
CGCUCCGUUUCCUUUUGC---|  A    A   U        A            UGAGGGUCUAUGAUAC 
                     CUG UUCC GGC GAGGUAGU GUUUGUACAGUU                \
                     GAC AAGG CCG UUCCGUCA CGGACAUGUCAA                C
GGGGUGAACCGUCGACCGCGC^  -    A   -        C            UAGAGGACAUGGCCCA 
      130       120        110        100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P2c3_5p

mirBase accession

MIMAT0000414

Sequence

0- UGAGGUAGUAGUUUGUACAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000414
TargetScanVert: hsa-let-7g-5p
TargetMiner: hsa-let-7g-5p
miRDB: MIMAT0000414

Star sequence

Hsa-Let-7-P2c3_3p*

mirBase accession

MIMAT0004584

Sequence

57- CUGUACAGGCCACUGCCUUGC -78

Get sequence

Proposed targets

microrna.org: MIMAT0004584
TargetScanVert: hsa-let-7g-3p
TargetMiner: hsa-let-7g-3p
miRDB: MIMAT0004584