Let-7-P2a3

MirGeneDB ID

Hsa-Let-7-P2a3

Family name

LET-7 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7f-2

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1c Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2b1 Hsa-Let-7-P2b2 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2a3 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2a3 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2a3 Cfa-Let-7-P2a3 Cja-Let-7-P2a3 Cpi-Let-7-P2a3 Cpo-Let-7-P2a3 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2a3 Dpu-Let-7 Dre-Let-7-P2a3a Dre-Let-7-P2a3b Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2a3 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2a3 Gja-Let-7-P2a3 Gmo-Let-7-P2a3a Gmo-Let-7-P2a3b Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P2a3 Lan-Let-7 Lch-Let-7-P2a3 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2a3 Mal-Let-7-P2a3a Mal-Let-7-P2a3b Mdo-Let-7-P2a3 Mgi-Let-7 Mml-Let-7-P2a3 Mmr-Let-7-P2a3 Mmu-Let-7-P2a3 Mom-Let-7 Mun-Let-7-P2a3 Neu-Let-7-P2a3 Npo-Let-7 Oan-Let-7-P2a3 Obi-Let-7 Ocu-Let-7-P2a3 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2a3 Pau-Let-7 Pbv-Let-7-P2a3 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2a3 Rph-Let-7 Sha-Let-7-P2a3 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2a3 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2a3 Tca-Let-7 Tgu-Let-7-P2a3 Tni-Let-7-P2a3a Tni-Let-7-P2a3b Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P2a3d Xtr-Let-7-P2a3

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chrX: 53557197-53557267 [-] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2a3)

Let-7-P2b3 chrX: 53556242-53556320 [-] UCSC Ensembl
Let-7-P2a3 chrX: 53557197-53557267 [-] UCSC Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

GCUGAAGAUGGACACUGGUGCUCUGUGGGAUGAGGUAGUAGAUUGUAUAGUUUUAGGGUCAUACCCCAUCUUGGAGAUAACUAUACAGUCUACUGUCUUUCCCACGGUGGUACACUUCUUCUCCGACUGGC

Get precursor sequence

Structure

        10         20         30        40        50        60     
GCUGAAGAUGGACACUG-     -|       U   GU                UUAGGGUCAUAC 
                  GUGCU CUGUGGGA GAG  AGUAGAUUGUAUAGUU            C
                  CAUGG GGCACCCU UUC  UCAUCUGACAUAUCAA            C
CGGUCAGCCUCUUCUUCA     U^       -   UG                UAGAGGUUCUAC 
 .       120       110       100         90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Yes

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P2a3_5p

mirBase accession

MIMAT0000067

Sequence

0- UGAGGUAGUAGAUUGUAUAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000067
TargetScanVert: hsa-let-7f-5p
TargetMiner: hsa-let-7f-5p
miRDB: MIMAT0000067

Star sequence

Hsa-Let-7-P2a3_3p*

mirBase accession

MIMAT0004487

Sequence

50- CUAUACAGUCUACUGUCUUUC -71

Get sequence

Proposed targets

microrna.org: MIMAT0004487
TargetScanVert: hsa-let-7f-2-3p
TargetMiner: hsa-let-7f-2-3p
miRDB: MIMAT0004487