MirGeneDB 3.0
MirGeneDB ID

Hsa-Let-7-P2c2

Family name LET-7 (all species)
Species Human (Homo sapiens)
MiRBase ID hsa-let-7i
Paralogues Hsa-Let-7-P1b  Hsa-Let-7-P1c  Hsa-Let-7-P1d  Hsa-Let-7-P2a1  Hsa-Let-7-P2a2  Hsa-Let-7-P2a3  Hsa-Let-7-P2b1  Hsa-Let-7-P2b2  Hsa-Let-7-P2b3  Hsa-Let-7-P2c1  Hsa-Let-7-P2c3 
Orthologues Aae-Let-7  Aca-Let-7-P2c2  Aga-Let-7  Agr-Let-7  Ami-Let-7-P2c2  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Bta-Let-7-P2c2  Cfa-Let-7-P2c2  Cja-Let-7-P2c2  Cli-Let-7-P2c2  Cmi-Let-7-P2c2  Cpi-Let-7-P2c2  Cpo-Let-7-P2c2  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dno-Let-7-P2c2  Dpu-Let-7  Dre-Let-7-P2c2b  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Eca-Let-7-P2c2  Egr-Let-7  Esc-Let-7  Ete-Let-7-P2c2  Gga-Let-7-P2c2  Gja-Let-7-P2c2  Gmo-Let-7-P2c2a  Gmo-Let-7-P2c2b  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Isc-Let-7  Laf-Let-7-P2c2  Lan-Let-7  Lch-Let-7-P2c2  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Loc-Let-7-P2c2  Mal-Let-7-P2c2b  Mdo-Let-7-P2c2  Mgi-Let-7  Mml-Let-7-P2c2  Mmr-Let-7-P2c2  Mmu-Let-7-P2c2  Mom-Let-7  Mun-Let-7-P2c2  Neu-Let-7-P2c2  Npo-Let-7  Oan-Let-7-P2c2  Obi-Let-7  Ocu-Let-7-P2c2  Ofu-Let-7  Ovu-Let-7  Pab-Let-7-P2c2  Pau-Let-7  Pbv-Let-7-P2c2  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rno-Let-7-P2c2  Rph-Let-7  Sha-Let-7-P2c2  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spt-Let-7-P2c2  Spu-Let-7  Sro-Let-7  Sto-Let-7-P2c2  Tca-Let-7  Tgu-Let-7-P2c2  Tni-Let-7-P2c2a  Tni-Let-7-P2c2b  Tur-Let-7  War-Let-7  Xbo-Let-7  Xla-Let-7-P2c2  Xtr-Let-7-P2c2 
Node of Origin (locus) Gnathostomata
Node of Origin (family) Bilateria
Genome context
(hg38)		 chr12: 62603691-62603767 [+] UCSC Ensembl
Seed GAGGUAG
Precursor
(pre-Mir +30nt flank)		 
CCCGUGCCUCCCCGACACCAUGGCCCUGGCUGAGGUAGUAGUUUGUGCUGUUGGUCGGGUUGUGACAUUGCCCGCUGUGGAGAUAACUGCGCAAGCUACUGCCUUGCUAGUGCUGGUGAUGCUCAGCGCCGCGGAGG
Get precursor sequence
Structure
        10            20        30        40        50        60        
CCCGUGCCUCCCCGACA----|  UG  C     U                 U   GGUCGGGUUGUGACA 
                     CCA  GC CUGGC GAGGUAGUAGUUUGUGC GUU               U
                     GGU  CG GAUCG UUCCGUCAUCGAACGCG CAA               U
GGAGGCGCCGCGACUCGUAGU^  --  U     -                 U   UAGAGGUGUCGCCCG 
     130       120         110        100        90        80        70
Deep sequencing
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CommentAlthough there is a templated thymidine at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' uridine is supported by the CAGE data from de Rie et al. (2017). All other vertebrates are treated accordingly.
3' NTU Yes
MotifsCNNC at 3p(+17)
Tissue expression
- +
Dc Dc Dr Dr Xp Xp Bl Br Br Ce Ce Co Fo He Ki Le Li Li Lu Pa Pl Pl Sk Sk Sk Sm Sp Sp St Te Th Ut
Mature sequence

Hsa-Let-7-P2c2_5p
mirBase accessionMIMAT0000415
Sequence 
0- UGAGGUAGUAGUUUGUGCUGUU -22
Get sequence
Proposed targets microrna.org: MIMAT0000415
TargetScanVert: hsa-let-7i-5p
TargetMiner: hsa-let-7i-5p
miRDB: MIMAT0000415
Star sequence

Hsa-Let-7-P2c2_3p*
mirBase accessionMIMAT0004585
Sequence 
56- CUGCGCAAGCUACUGCCUUGC -77
Get sequence
Proposed targets microrna.org: MIMAT0004585
TargetScanVert: hsa-let-7i-3p
TargetMiner: hsa-let-7i-3p
miRDB: MIMAT0004585