Let-7-P2b2

MirGeneDB ID

Hsa-Let-7-P2b2

Family name

LET-7 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-let-7b

Paralogues

Hsa-Let-7-P1b Hsa-Let-7-P1c Hsa-Let-7-P1d Hsa-Let-7-P2a1 Hsa-Let-7-P2a2 Hsa-Let-7-P2a3 Hsa-Let-7-P2b1 Hsa-Let-7-P2b3 Hsa-Let-7-P2c1 Hsa-Let-7-P2c2 Hsa-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2b2 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2b2 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2b2 Cfa-Let-7-P2b2 Cja-Let-7-P2b2 Cli-Let-7-P2b2 Cmi-Let-7-P2b2 Cpi-Let-7-P2b2 Cpo-Let-7-P2b2 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2b2 Dpu-Let-7 Dre-Let-7-P2b2a Dre-Let-7-P2b2b Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2b2 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2b2 Gga-Let-7-P2b2 Gja-Let-7-P2b2 Gmo-Let-7-P2b2a Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Laf-Let-7-P2b2 Lan-Let-7 Lch-Let-7-P2b2 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2b2 Mal-Let-7-P2b2a Mal-Let-7-P2b2b Mdo-Let-7-P2b2 Mgi-Let-7 Mml-Let-7-P2b2 Mmr-Let-7-P2b2 Mmu-Let-7-P2b2 Mom-Let-7 Mun-Let-7-P2b2 Neu-Let-7-P2b2 Npo-Let-7 Oan-Let-7-P2b2 Obi-Let-7 Ocu-Let-7-P2b2 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2b2 Pau-Let-7 Pbv-Let-7-P2b2 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2b2 Rph-Let-7 Sha-Let-7-P2b2 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2b2 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2b2 Tca-Let-7 Tgu-Let-7-P2b2 Tni-Let-7-P2b2a Tni-Let-7-P2b2b Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P2b2c Xla-Let-7-P2b2d Xtr-Let-7-P2b2

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr22: 46113691-46113765 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2b2)

Mir-3619 chr22: 46091059-46091112 [+] UCSC Ensembl
Let-7-P2a2 chr22: 46112752-46112820 [+] UCSC Ensembl
Let-7-P2b2 chr22: 46113691-46113765 [+] UCSC Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

UCCCGCAGUGCAAGGCCGGGCCUGGCGGGGUGAGGUAGUAGGUUGUGUGGUUUCAGGGCAGUGAUGUUGCCCCUCGGAAGAUAACUAUACAACCUACUGCCUUCCCUGAGGAGCCCAGUGACACGACCCCAUGGG

Get precursor sequence

Structure

        10          20         30        40        50        60       
UCCCGCAGUGCAAGGCC--    -| GG     U                     UCAGGGCAGUGAUG 
                   GGGC CU  CGGGG GAGGUAGUAGGUUGUGUGGUU              U
                   CCCG GG  GUCCC UUCCGUCAUCCAACAUAUCAA              U
GGGUACCCCAGCACAGUGA    A^ A-     -                     UAGAAGGCUCCCCG 
   130       120       110         100        90        80        70

Deep sequencing

Go to detailed chart

3' NTU

Yes

Motifs

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Let-7-P2b2_5p

mirBase accession

MIMAT0000063

Sequence

0- UGAGGUAGUAGGUUGUGUGGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0000063
TargetScanVert: hsa-let-7b-5p
TargetMiner: hsa-let-7b-5p
miRDB: MIMAT0000063

Star sequence

Hsa-Let-7-P2b2_3p*

mirBase accession

MIMAT0004482

Sequence

54- CUAUACAACCUACUGCCUUCC -75

Get sequence

Proposed targets

microrna.org: MIMAT0004482
TargetScanVert: hsa-let-7b-3p
TargetMiner: hsa-let-7b-3p
miRDB: MIMAT0004482