Mir-34-P2a

MirGeneDB ID

Hsa-Mir-34-P2a

Family name

MIR-34 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-mir-34b

Paralogues

Hsa-Mir-34-P1 Hsa-Mir-34-P2b Hsa-Mir-34-P3a-v1 Hsa-Mir-34-P3b Hsa-Mir-34-P3c

Orthologues

Aae-Mir-34 Aca-Mir-34-P2a Aga-Mir-34 Agr-Mir-34 Ami-Mir-34-P2a Asu-Mir-34 Bge-Mir-34 Bta-Mir-34-P2a Cbr-Mir-34 Cel-Mir-34 Cfa-Mir-34-P2a Cin-Mir-34 Cja-Mir-34-P2a Cli-Mir-34-P2a Cmi-Mir-34-P2a Cpi-Mir-34-P2a Cpo-Mir-34-P2a Cte-Mir-34 Dan-Mir-34 Dlo-Mir-34 Dma-Mir-34 Dme-Mir-34 Dmo-Mir-34 Dno-Mir-34-P2a Dpu-Mir-34 Dre-Mir-34-P2a Dsi-Mir-34 Dya-Mir-34 Ebu-Mir-34-P2a Eca-Mir-34-P2a Efe-Mir-34 Esc-Mir-34 Ete-Mir-34-P2a Gga-Mir-34-P2a Gja-Mir-34-P2a Gpa-Mir-34 Gsp-Mir-34 Hmi-Mir-34 Hru-Mir-34 Isc-Mir-34 Laf-Mir-34-P2a Lch-Mir-34-P2a Lgi-Mir-34 Lhy-Mir-34 Llo-Mir-34 Loc-Mir-34-P2a Mdo-Mir-34-P2a Mgi-Mir-34 Mml-Mir-34-P2a Mmr-Mir-34-P2a Mmu-Mir-34-P2a Mom-Mir-34 Mun-Mir-34-P2a Neu-Mir-34-P2a-v1 Npo-Mir-34 Oan-Mir-34-P2a Obi-Mir-34 Ocu-Mir-34-P2a Ofu-Mir-34 Ovu-Mir-34 Pab-Mir-34-P2a Pau-Mir-34 Pbv-Mir-34-P2a Pca-Mir-34 Pdu-Mir-34 Pfl-Mir-34 Pmi-Mir-34 Pve-Mir-34 Rno-Mir-34-P2a Rph-Mir-34 Sha-Mir-34-P2a Sko-Mir-34 Snu-Mir-34 Spt-Mir-34-P2a Spu-Mir-34 Sto-Mir-34-P2a Tca-Mir-34 Tgu-Mir-34-P2a Tur-Mir-34 War-Mir-34 Xla-Mir-34-P2a1a Xla-Mir-34-P2a1b Xla-Mir-34-P2a2a Xla-Mir-34-P2a2b Xtr-Mir-34-P2a1 Xtr-Mir-34-P2a2

Node of Origin (locus)

Vertebrata

Node of Origin (family)

Bilateria

Genome context
(hg38)

chr11: 111512951-111513009 [+] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-34-P2a)

Mir-34-P2a chr11: 111512951-111513009 [+] UCSC Ensembl
Mir-34-P2b chr11: 111513451-111513505 [+] UCSC Ensembl

Seed

GGCAGUG

Precursor
(pre-Mir +30nt flank)

GCAGCCGCGGGUGCCCGGUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCACAGCAUCACCGCCGCCCGG

Get precursor sequence

Structure

        10         20        30         40        50         
GCAGCCGCGGGUGCCCG-     CG    GUA-|      UCA    C       ACUGU 
                  GUGCU  GUUU    GGCAGUG   UUAG UGAUUGU     G
                  CACGG  CAAA    CCGUCAC   AAUC ACUAACA     G
GGCCCGCCGCCACUACGA     AA    ACUA^      CUC    -       UUGGU 
       110       100        90        80         70        60

Deep sequencing

Go to detailed chart

Comment

There is a second Dicer cut +1 on the 3p arm.

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Mir-34-P2a_5p

mirBase accession

MIMAT0000685

Sequence

0- AGGCAGUGUCAUUAGCUGAUUGU -23

Get sequence

Proposed targets

microrna.org: MIMAT0000685
TargetScanVert: hsa-miR-34b-5p
TargetMiner: hsa-miR-34b-5p
miRDB: MIMAT0000685

Co-mature sequence

Hsa-Mir-34-P2a_3p

mirBase accession

MIMAT0004676

Sequence

37- AAUCACUAACUCCACUGCCAUC -59

Get sequence

Proposed targets

microrna.org: MIMAT0004676
TargetScanVert: hsa-miR-34b-3p
TargetMiner: hsa-miR-34b-3p
miRDB: MIMAT0004676