MirGeneDB 3.0
MirGeneDB ID

Rno-Mir-216-P2a

Family name MIR-216 (all species)
Species Norway rat (Rattus norvegicus)
MiRBase ID rno-mir-216b
Paralogues Rno-Mir-216-P2b 
Orthologues Aae-Mir-216-P2  Aca-Mir-216-P2a  Aga-Mir-216-P2  Ami-Mir-216-P2a  Asu-Mir-216-P2  Ava-Mir-216-P2  Bfl-Mir-216-P2  Bge-Mir-216-P2  Bko-Mir-216-P2  Bla-Mir-216-P2  Bpl-Mir-216-P2  Bta-Mir-216-P2a  Cbr-Mir-216-P2  Cel-Mir-216-P2  Cfa-Mir-216-P2a  Cja-Mir-216-P2a  Cli-Mir-216-P2a  Cmi-Mir-216-P2a  Cpi-Mir-216-P2a  Cpo-Mir-216-P2a  Csc-Mir-216-P2  Dan-Mir-216-P2  Dlo-Mir-216-P2  Dma-Mir-216-P2  Dme-Mir-216-P2  Dmo-Mir-216-P2  Dno-Mir-216-P2a  Dpu-Mir-216-P2  Dre-Mir-216-P2a  Dsi-Mir-216-P2  Dya-Mir-216-P2  Ebu-Mir-216-P2a2  Eca-Mir-216-P2a  Ete-Mir-216-P2a  Gga-Mir-216-P2a  Gja-Mir-216-P2a  Gmo-Mir-216-P2a  Hme-Mir-216-P2  Hsa-Mir-216-P2a  Isc-Mir-216-P2  Laf-Mir-216-P2a  Lch-Mir-216-P2a  Loc-Mir-216-P2a  Mal-Mir-216-P2a  Mdo-Mir-216-P2a  Mml-Mir-216-P2a  Mmr-Mir-216-P2a  Mmu-Mir-216-P2a  Neu-Mir-216-P2a  Oan-Mir-216-P2a  Ocu-Mir-216-P2a  Pab-Mir-216-P2a  Pbv-Mir-216-P2a  Pca-Mir-216-P2  Pma-Mir-216-P2a1  Pma-Mir-216-P2a2  Sha-Mir-216-P2a  Spt-Mir-216-P2a  Sto-Mir-216-P2a  Tca-Mir-216-P2  Tgu-Mir-216-P2a  Tni-Mir-216-P2a  Tur-Mir-216-P2 
Node of Origin (locus) Vertebrata
Node of Origin (family) Nephrozoa
Genome context
(rn6)		 chr14: 113101097-113101158 [+] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-216-P2a)		 Mir-216-P2a chr14: 113101097-113101158 [+] UCSC Ensembl
Mir-216-P2b chr14: 113112147-113112208 [+] UCSC Ensembl
Mir-217-v2 chr14: 113119559-113119619 [+] UCSC Ensembl
Mir-217-v1 chr14: 113119560-113119618 [+] UCSC Ensembl
Seed AAUCUCU
Precursor
(pre-Mir +30nt flank)		 
UUCCAUGUAAUUGCACGUUGGCAGACUGGGAAAUCUCUGCAGGCAAAUGUGAUGUCACUGAAGAAAUCACACACUUACUUGUAGAGAUUCUUCAGUCUGACAACAUCAAGCAUCAAAUCCCU
Get precursor sequence
Structure
        10          20        30        40        50        60
UUCCAUGUAAUUGCACG--|  G        GA            C  A    AUGUCACU 
                   UUG CAGACUGG  AAUCUCUGCAGG AA UGUG        G
                   AAC GUCUGACU  UUAGAGAUGUUC UU ACAC        A
UCCCUAAACUACGAACUAC^  A        UC            A  C    ACUAAAGA 
120       110       100        90        80        70
Deep sequencing
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CommentThis gene was named Mir-216-P1 in MirGene 1.0 but it appears that there are two ancestral copies of Mir-216 with the second copy found only in protostomes and the two copies in vertebrates a vertebrate-specific gene duplication of one of these two ancestral paralogues.
3' NTU No
MotifsUGUG in loop
Tissue expression
- +
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Mature sequence

Rno-Mir-216-P2a_5p
mirBase accessionMIMAT0017846
Sequence 
0- AAAUCUCUGCAGGCAAAUGUGA -22
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Proposed targets TargetScanVert: rno-miR-216b-5p
miRDB: MIMAT0017846
Star sequence

Rno-Mir-216-P2a_3p*
mirBase accessionMIMAT0017847
Sequence 
40- ACACUUACUUGUAGAGAUUCUU -62
Get sequence
Proposed targets TargetScanVert: rno-miR-216b-3p
miRDB: MIMAT0017847