Mir-22-P2b

MirGeneDB ID

Bla-Mir-22-P2b

Family name

Species

European lancelet (Branchiostoma lanceolatum)

MiRBase ID

Paralogues

Bla-Mir-22-o3a1a Bla-Mir-22-o3a1b Bla-Mir-22-o3a1c Bla-Mir-22-o3a1d Bla-Mir-22-o3a2a Bla-Mir-22-o3a2b Bla-Mir-22-o3a3 Bla-Mir-22-o3b1 Bla-Mir-22-o3b2 Bla-Mir-22-o3b3 Bla-Mir-22-o3c1 Bla-Mir-22-o3c2 Bla-Mir-22-P1 Bla-Mir-22-P2a Bla-Mir-22-P2c

Orthologues

Aae-Mir-22-P2 Aga-Mir-22-P2 Agr-Mir-22-P2 Asu-Mir-22-P2 Bfl-Mir-22-P2b Bge-Mir-22-P2 Cbr-Mir-22-P2-v1 Cel-Mir-22-P2 Csc-Mir-22-P2 Cte-Mir-22-P2 Dan-Mir-22-P2 Dlo-Mir-22-P2 Dma-Mir-22-P2 Dme-Mir-22-P2 Dmo-Mir-22-P2 Dpu-Mir-22-P2 Dsi-Mir-22-P2 Dya-Mir-22-P2 Eba-Mir-22-P2 Esc-Mir-22-P2 Gpa-Mir-22-P2 Hme-Mir-22-P2 Hru-Mir-22-P2 Isc-Mir-22-P2 Lan-Mir-22-P2 Lgi-Mir-22-P2 Lhy-Mir-22-P2 Llo-Mir-22-P2 Mgi-Mir-22-P2 Mom-Mir-22-P2 Npo-Mir-22-P2 Ovu-Mir-22-P2 Pau-Mir-22-P2 Pca-Mir-22-P2 Pdu-Mir-22-P2 Pfl-Mir-22-P2 Pmi-Mir-22-P2 Pve-Mir-22-P2 Rph-Mir-22-P2 Sko-Mir-22-P2 Snu-Mir-22-P2 Spu-Mir-22-P2 Tca-Mir-22-P2-v1 Tur-Mir-22-P2 War-Mir-22-P2

Node of Origin (locus)

Branchiostoma

Node of Origin (family)

Bilateria

Genome context
(BraLan2)

Sc0000017: 1346304-1346363 [-] Ensembl

Clustered miRNAs
(< 50kb from Mir-22-P2b)

Mir-184 Sc0000017: 1306129-1306193 [+] Ensembl
Mir-22-P2b Sc0000017: 1346304-1346363 [-] Ensembl
Mir-22-P2a Sc0000017: 1361498-1361557 [-] Ensembl

Seed

CAGCUCC

Precursor
(pre-Mir +30nt flank)

CUUUUCUGUAUCGUAAGCGUGUCAGCUUCCCUCAUCACACCGGAAGCUGUUACGUCACUUCCGUUGUAUCAGCUCCAGCUGUGAUGAGUGAAGAGGCAUGCGCAGAACAACAAACCAACG

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Structure

        10           20        30        40         50         
CUUUUCUGUAUCGUAAG---|     AG    C         CC-   A    U  CGUCAC 
                    CGUGUC  CUUC CUCAUCACA   GGA GCUG UA      U
                    GUACGG  GAAG GAGUAGUGU   CCU CGAC AU      U
GCAACCAAACAACAAGACGC^     A-    U         CGA   -    U  GUUGCC 
.       110       100         90        80         70        60

Deep sequencing

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Comment

It is unclear if this paralogue group represents the ancestral Mir-22-P2 gene that is seed shifted or a new paralogue derived from the ancestral P1 gene. It is also unclear if this gene is orthologous to the Mir-22-o2 gene in ambulacrarians.

3' NTU

Motifs

CNNC at 3p(+17)

Tissue expression

Ad	Ad	Em	Em	Em	Em

Star sequence

Bla-Mir-22-P2b_5p*

mirBase accession

None

Sequence

0- CUCAUCACACCGGAAGCUGUUA -22

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Mature sequence

Bla-Mir-22-P2b_3p

mirBase accession

None

Sequence

38- UCAGCUCCAGCUGUGAUGAGUG -60

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