Let-7-P2a1a

MirGeneDB ID

Dre-Let-7-P2a1a

Family name

LET-7 (all species)

Species

Zebrafish (Danio rerio)

MiRBase ID

dre-let-7a-1

Paralogues

Dre-Let-7-P1b1 Dre-Let-7-P1b2 Dre-Let-7-P1c1 Dre-Let-7-P1c2 Dre-Let-7-P1d1 Dre-Let-7-P1d2 Dre-Let-7-P2a2a Dre-Let-7-P2a2b Dre-Let-7-P2a3a Dre-Let-7-P2a3b Dre-Let-7-P2a4a Dre-Let-7-P2a4b Dre-Let-7-P2b1a Dre-Let-7-P2b2a Dre-Let-7-P2b2b Dre-Let-7-P2b3a Dre-Let-7-P2b4a Dre-Let-7-P2b4b Dre-Let-7-P2c2b Dre-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2a1 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2a1 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2a1 Cfa-Let-7-P2a1 Cja-Let-7-P2a1 Cli-Let-7-P2a1 Cmi-Let-7-P2a1 Cpi-Let-7-P2a1 Cpo-Let-7-P2a1 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2a1 Dpu-Let-7 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2a1 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2a1 Gga-Let-7-P2a1 Gja-Let-7-P2a1 Gmo-Let-7-P2a1a Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Hsa-Let-7-P2a1 Isc-Let-7 Laf-Let-7-P2a1 Lan-Let-7 Lch-Let-7-P2a1 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Loc-Let-7-P2a1 Mal-Let-7-P2a1a Mdo-Let-7-P2a1 Mgi-Let-7 Mml-Let-7-P2a1 Mmr-Let-7-P2a1 Mmu-Let-7-P2a1 Mom-Let-7 Mun-Let-7-P2a1 Npo-Let-7 Oan-Let-7-P2a1 Obi-Let-7 Ocu-Let-7-P2a1 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2a1 Pau-Let-7 Pbv-Let-7-P2a1 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2a1 Rph-Let-7 Sha-Let-7-P2a1 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2a1 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2a1 Tca-Let-7 Tgu-Let-7-P2a1 Tur-Let-7 War-Let-7 Xbo-Let-7 Xla-Let-7-P2a1c Xla-Let-7-P2a1d Xtr-Let-7-P2a1

Node of Origin (locus)

Clupeocephala

Node of Origin (family)

Bilateria

Genome context
(danRer11)

chr11: 27503240-27503310 [-] UCSC Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2a1a)

Let-7-P2b1a chr11: 27503037-27503113 [-] UCSC Ensembl
Let-7-P2a1a chr11: 27503240-27503310 [-] UCSC Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

UGGACUGGAGGUUACAUGUUGACGGUGGGAUGAGGUAGUAGGUUGUAUAGUUUUAGGGUCACACCCACACUGGGAGAUAACUAUACAACCUACUGUCUUUCUCAAAGUCCAAAUCAAGCUACAGAGUUUCA

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Structure

        10        20          30        40        50        60     
UGGACUGGAGGUUACAUGUU--|  GG     U   GU                UUAGGGUCACAC 
                      GAC  UGGGA GAG  AGUAGGUUGUAUAGUU            C
                      CUG  ACUCU UUC  UCAUCCAACAUAUCAA            C
ACUUUGAGACAUCGAACUAAAC^  AA     -   UG                UAGAGGGUCACA 
 .       120       110       100         90        80        70

Deep sequencing

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Comment

Although there is a templated T at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' U is supported by the CAGE data from de Rie et al. (2017).

3' NTU

Yes

Motifs

UG at 5p(-14), CNNC at 3p(+17)

Tissue expression

Br	Br	Em	Ey	Gu	Gu	He	Li	Li	Ov	Te

Mature sequence

Dre-Let-7-P2a1a_5p

mirBase accession

MIMAT0001759

Sequence

0- UGAGGUAGUAGGUUGUAUAGUU -22

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Proposed targets

TargetScanFish: dre-let-7a

Star sequence

Dre-Let-7-P2a1a_3p*

mirBase accession

None

Sequence

50- CUAUACAACCUACUGUCUUUC -71

Get sequence