MirGeneDB 3.0
MirGeneDB ID

Mdo-Let-7-P2a1

Family name LET-7 (all species)
Species Gray short-tailed opossum (Monodelphis domestica)
MiRBase ID mdo-let-7a-1
Paralogues Mdo-Let-7-P1b  Mdo-Let-7-P1d  Mdo-Let-7-P2a2  Mdo-Let-7-P2a3  Mdo-Let-7-P2b1  Mdo-Let-7-P2b2  Mdo-Let-7-P2c1  Mdo-Let-7-P2c2  Mdo-Let-7-P2c3 
Orthologues Aae-Let-7  Aca-Let-7-P2a1  Aga-Let-7  Agr-Let-7  Ami-Let-7-P2a1  Bge-Let-7  Bko-Let-7  Bpl-Let-7  Bta-Let-7-P2a1  Cfa-Let-7-P2a1  Cja-Let-7-P2a1  Cli-Let-7-P2a1  Cmi-Let-7-P2a1  Cpi-Let-7-P2a1  Cpo-Let-7-P2a1  Cte-Let-7  Dan-Let-7  Dlo-Let-7  Dma-Let-7  Dme-Let-7  Dmo-Let-7  Dno-Let-7-P2a1  Dpu-Let-7  Dre-Let-7-P2a1a  Dsi-Let-7  Dya-Let-7  Eba-Let-7  Eca-Let-7-P2a1  Egr-Let-7  Esc-Let-7  Ete-Let-7-P2a1  Gga-Let-7-P2a1  Gja-Let-7-P2a1  Gmo-Let-7-P2a1a  Gpa-Let-7  Gsa-Let-7  Gsp-Let-7  Hme-Let-7  Hmi-Let-7  Hru-Let-7  Hsa-Let-7-P2a1  Isc-Let-7  Laf-Let-7-P2a1  Lan-Let-7  Lch-Let-7-P2a1  Lgi-Let-7  Lhy-Let-7  Llo-Let-7  Loc-Let-7-P2a1  Mal-Let-7-P2a1a  Mgi-Let-7  Mml-Let-7-P2a1  Mmr-Let-7-P2a1  Mmu-Let-7-P2a1  Mom-Let-7  Mun-Let-7-P2a1  Npo-Let-7  Oan-Let-7-P2a1  Obi-Let-7  Ocu-Let-7-P2a1  Ofu-Let-7  Ovu-Let-7  Pab-Let-7-P2a1  Pau-Let-7  Pbv-Let-7-P2a1  Pca-Let-7  Pcr-Let-7  Pdu-Let-7  Pfl-Let-7  Ple-Let-7  Pmi-Let-7  Pve-Let-7  Rno-Let-7-P2a1  Rph-Let-7  Sha-Let-7-P2a1  Sko-Let-7  Sma-Let-7  Sne-Let-7  Snu-Let-7  Spt-Let-7-P2a1  Spu-Let-7  Sro-Let-7  Sto-Let-7-P2a1  Tca-Let-7  Tgu-Let-7-P2a1  Tur-Let-7  War-Let-7  Xbo-Let-7  Xla-Let-7-P2a1c  Xla-Let-7-P2a1d  Xtr-Let-7-P2a1 
Node of Origin (locus) Gnathostomata
Node of Origin (family) Bilateria
Genome context
(monDom5_add)		 6: 256413199-256413270 [-] UCSC Ensembl
Clustered miRNAs
(< 50kb from Let-7-P2a1)		 Let-7-P2c1 6: 256407639-256407713 [-] UCSC Ensembl
Let-7-P2b1 6: 256412448-256412524 [-] UCSC Ensembl
Let-7-P2a1 6: 256413199-256413270 [-] UCSC Ensembl
Seed GAGGUAG
Precursor
(pre-Mir +30nt flank)		 
CUACAACUAAAACAAAUCUCCACUGUGGGAUGAGGUAGUAGGUUGUAUAGUUUUAGGGUCACACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUUUCUUAAAGUGGGAGGAAAUCUCCAGGAGUAUU
Get precursor sequence
Structure
        10          20        30        40        50        60      
CUACAACUAAAACAAAU-  -|    G     U   GU                UUAGGGUCACACC 
                  CU CCACU UGGGA GAG  AGUAGGUUGUAUAGUU             \
                  GA GGUGA AUUCU UUC  UCAUCUAACAUAUCAA             C
UUAUGAGGACCUCUAAAG  G^    A     -   UG                UAGAGGGUCACCA 
130       120       110        100        90        80        70
Deep sequencing
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CommentAlthough there is a templated T at the 3' end of the 3p arm, the post-transcriptional addition of a terminal 3' U in human is supported by the CAGE data from de Rie et al. (2017).
3' NTU Yes
MotifsCNNC at 3p(+17)
Tissue expression
- +
Br Ce He Ki Te
Mature sequence

Mdo-Let-7-P2a1_5p
mirBase accessionMIMAT0004141
Sequence 
0- UGAGGUAGUAGGUUGUAUAGUU -22
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Proposed targets TargetScanVert: mdo-let-7a-5p
Star sequence

Mdo-Let-7-P2a1_3p*
mirBase accessionNone
Sequence 
51- CUAUACAAUCUACUGUCUUUC -72
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