Let-7-P2c1

MirGeneDB ID

Loc-Let-7-P2c1

Family name

Species

MiRBase ID

Paralogues

Loc-Let-7-P1b Loc-Let-7-P1c Loc-Let-7-P1d Loc-Let-7-P2a1 Loc-Let-7-P2a2 Loc-Let-7-P2a3 Loc-Let-7-P2a4 Loc-Let-7-P2b1 Loc-Let-7-P2b2 Loc-Let-7-P2b3 Loc-Let-7-P2b4 Loc-Let-7-P2c2 Loc-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2c1 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2c1 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Bta-Let-7-P2c1 Cfa-Let-7-P2c1 Cja-Let-7-P2c1 Cli-Let-7-P2c1 Cmi-Let-7-P2c1 Cpi-Let-7-P2c1 Cpo-Let-7-P2c1 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dno-Let-7-P2c1 Dpu-Let-7 Dsi-Let-7 Dya-Let-7 Eba-Let-7 Eca-Let-7-P2c1 Egr-Let-7 Esc-Let-7 Ete-Let-7-P2c1 Gga-Let-7-P2c1 Gja-Let-7-P2c1 Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Hsa-Let-7-P2c1 Isc-Let-7 Laf-Let-7-P2c1 Lan-Let-7 Lch-Let-7-P2c1 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Mdo-Let-7-P2c1 Mgi-Let-7 Mml-Let-7-P2c1 Mmr-Let-7-P2c1 Mmu-Let-7-P2c1 Mom-Let-7 Mun-Let-7-P2c1 Neu-Let-7-P2c1 Npo-Let-7 Oan-Let-7-P2c1 Obi-Let-7 Ocu-Let-7-P2c1 Ofu-Let-7 Ovu-Let-7 Pab-Let-7-P2c1 Pau-Let-7 Pbv-Let-7-P2c1 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rno-Let-7-P2c1 Rph-Let-7 Sha-Let-7-P2c1 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2c1 Spu-Let-7 Sro-Let-7 Sto-Let-7-P2c1 Tca-Let-7 Tgu-Let-7-P2c1 Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(LepOcu1)

LG5: 47689931-47690005 [-] Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2c1)

Let-7-P2c1 LG5: 47689931-47690005 [-] Ensembl
Let-7-P2b1 LG5: 47690750-47690826 [-] Ensembl
Let-7-P2a1 LG5: 47691346-47691416 [-] Ensembl

Seed

GAAGUAG

Precursor
(pre-Mir +30nt flank)

GAAAGUGAGAGGAAAGCUGGGCUCUUAGGUAGAAGUAGCAGGUUCCAUAGUUGUAGGGCAGCAAUCUUAUCCCACAGGAGGUAACUAUACAACCUGUUGCCUUUCUUAGUGCUACACGGUUACAGCUAUCUAAUU

Get precursor sequence

Structure

        10           20        30        40        50        60       
GAAAGUGAGAGGAAAGCUG---|  U  U   U   A          CC      GUAGGGCAGCAAUC 
                      GGC CU AGG AGA GUAGCAGGUU  AUAGUU              U
                      UCG GA UUC UUU CGUUGUCCAA  UAUCAA              U
UUAAUCUAUCGACAUUGGCACA^  U  -   -   C          CA      UGGAGGACACCCUA 
   130       120       110         100        90        80        70

Deep sequencing

Comment

This might be an example of a recently lost miRNA gene as there are mutations in the seed and no reads detected in the small RNA library but possesses a canonical secondary structure.

3' NTU

Unknown

Motifs

CNNC at 3p(+17)

Tissue expression

Br	Br	He	He	He	He	Ov	Ov	Ov	Ov	Te	Te	Te	Te	To

Mature sequence

Loc-Let-7-P2c1_5p (predicted)

mirBase accession

None

Sequence

0- AGAAGUAGCAGGUUCCAUAGUU -22

Get sequence

Star sequence

Loc-Let-7-P2c1_3p* (predicted)

mirBase accession

None

Sequence

54- CUAUACAACCUGUUGCCUUUC -75

Get sequence