Let-7-P2a4

MirGeneDB ID

Loc-Let-7-P2a4

Family name

Species

MiRBase ID

Paralogues

Loc-Let-7-P1b Loc-Let-7-P1c Loc-Let-7-P1d Loc-Let-7-P2a1 Loc-Let-7-P2a2 Loc-Let-7-P2a3 Loc-Let-7-P2b1 Loc-Let-7-P2b2 Loc-Let-7-P2b3 Loc-Let-7-P2b4 Loc-Let-7-P2c1 Loc-Let-7-P2c2 Loc-Let-7-P2c3

Orthologues

Aae-Let-7 Aca-Let-7-P2a4 Aga-Let-7 Agr-Let-7 Ami-Let-7-P2a4 Bge-Let-7 Bko-Let-7 Bpl-Let-7 Cli-Let-7-P2a4 Cmi-Let-7-P2a4 Cpi-Let-7-P2a4 Cte-Let-7 Dan-Let-7 Dlo-Let-7 Dma-Let-7 Dme-Let-7 Dmo-Let-7 Dpu-Let-7 Dre-Let-7-P2a4a Dre-Let-7-P2a4b Dsi-Let-7 Dya-Let-7 Eba-Let-7 Egr-Let-7 Esc-Let-7 Gga-Let-7-P2a4 Gja-Let-7-P2a4 Gmo-Let-7-P2a4a Gmo-Let-7-P2a4b Gpa-Let-7 Gsa-Let-7 Gsp-Let-7 Hme-Let-7 Hmi-Let-7 Hru-Let-7 Isc-Let-7 Lan-Let-7 Lch-Let-7-P2a4 Lgi-Let-7 Lhy-Let-7 Llo-Let-7 Mal-Let-7-P2a4a Mal-Let-7-P2a4b Mgi-Let-7 Mom-Let-7 Mun-Let-7-P2a4 Npo-Let-7 Oan-Let-7-P2a4 Obi-Let-7 Ofu-Let-7 Ovu-Let-7 Pau-Let-7 Pbv-Let-7-P2a4 Pca-Let-7 Pcr-Let-7 Pdu-Let-7 Pfl-Let-7 Ple-Let-7 Pmi-Let-7 Pve-Let-7 Rph-Let-7 Sko-Let-7 Sma-Let-7 Sne-Let-7 Snu-Let-7 Spt-Let-7-P2a4 Spu-Let-7 Sro-Let-7 Tca-Let-7 Tgu-Let-7-P2a4 Tni-Let-7-P2a4a Tni-Let-7-P2a4b Tur-Let-7 War-Let-7 Xbo-Let-7

Node of Origin (locus)

Gnathostomata

Node of Origin (family)

Bilateria

Genome context
(LepOcu1)

LG3: 23239512-23239584 [-] Ensembl

Clustered miRNAs
(< 50kb from Let-7-P2a4)

Let-7-P2b4 LG3: 23239112-23239188 [-] Ensembl
Let-7-P2a4 LG3: 23239512-23239584 [-] Ensembl

Seed

GAGGUAG

Precursor
(pre-Mir +30nt flank)

UUUCUGCAAAUGUAAUGCUGUCCUUGGGGCUGAGGUAGUAGAUUGAAUAGUUGUGGGGUUUUUGUACUCCCUCUGAGAUAACUAUACAAUCUACUGUCUUUCCUAAGGAGACAGUCAAGUCAUCUACCAUUGA

Get precursor sequence

Structure

        10          20          30        40        50        60      
UUUCUGCAAAUGUAAUG--   --|        CU   GU         A      GUGGGGUUUUUGU 
                   CUG  UCCUUGGGG  GAG  AGUAGAUUG AUAGUU             \
                   GAC  AGGAAUCCU  UUC  UCAUCUAAC UAUCAA             A
AGUUACCAUCUACUGAACU   AG^        --   UG         A      UAGAGUCUCCCUC 
 130       120       110         100        90        80        70

Deep sequencing

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Comment

There is a second Dicer cut -1 on both arms and this second Dicer cut is likely monouridulated at the 3' end.

3' NTU

Yes

Motifs

CNNC at 3p(+17), UGUG in loop

Tissue expression

Br	Br	He	He	He	He	Ov	Ov	Ov	Ov	Te	Te	Te	Te	To

Mature sequence

Loc-Let-7-P2a4_5p

mirBase accession

None

Sequence

0- UGAGGUAGUAGAUUGAAUAGUU -22

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Star sequence

Loc-Let-7-P2a4_3p*

mirBase accession

None

Sequence

51- CUAUACAAUCUACUGUCUUUCC -73

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