Mir-451

MirGeneDB ID

Hsa-Mir-451

Family name

MIR-451 (all species)

Species

Human (Homo sapiens)

MiRBase ID

hsa-mir-451a

Paralogues

Orthologues

Aca-Mir-451 Ami-Mir-451 Bta-Mir-451 Cfa-Mir-451 Cja-Mir-451 Cli-Mir-451 Cmi-Mir-451 Cpi-Mir-451 Cpo-Mir-451 Dno-Mir-451 Dre-Mir-451 Ebu-Mir-451 Eca-Mir-451 Ete-Mir-451 Gga-Mir-451 Gja-Mir-451 Gmo-Mir-451 Laf-Mir-451 Lch-Mir-451 Loc-Mir-451 Mal-Mir-451 Mdo-Mir-451 Mml-Mir-451 Mmr-Mir-451 Mmu-Mir-451 Mun-Mir-451 Neu-Mir-451 Oan-Mir-451 Ocu-Mir-451 Pab-Mir-451 Pma-Mir-451 Rno-Mir-451 Sha-Mir-451 Spt-Mir-451 Sto-Mir-451 Tgu-Mir-451 Tni-Mir-451 Xla-Mir-451-P1 Xla-Mir-451-P2 Xtr-Mir-451

Node of Origin (locus)

Vertebrata

Node of Origin (family)

Vertebrata

Genome context
(hg38)

chr17: 28861383-28861424 [-] UCSC Ensembl

Clustered miRNAs
(< 50kb from Mir-451)

Mir-451 chr17: 28861383-28861424 [-] UCSC Ensembl
Mir-144-v1 chr17: 28861547-28861604 [-] UCSC Ensembl
Mir-144-v2 chr17: 28861547-28861604 [-] UCSC Ensembl

Seed

AACCGUU

Precursor
(pre-Mir +30nt flank)

UGACUGCCAGGGCACUUGGGAAUGGCAAGGAAACCGUUACCAUUACUGAGUUUAGUAAUGGUAAUGGUUCUCUUGCUAUACCCAGAAAACGUGCCAGGAAGA

Get precursor sequence

Structure

        10          20        30        40        50
UGACUGCCAGGGCACUU--|  A        GA                 A 
                   GGG AUGGCAAG  AACCGUUACCAUUACUG G
                   CCC UAUCGUUC  UUGGUAAUGGUAAUGAU U
AGAAGGACCGUGCAAAAGA^  A        UC                 U 
100        90        80        70        60

Deep sequencing

Go to detailed chart

Comment

As a non-canonical (Group 4, Kim et al. 2016) miRNA there is no discrete 3p read and the 3' end of the mature miRNA is somewhat arbitrary.

3' NTU

Motifs

UG at 5p(-14)

Tissue expression

Dc	Dc	Dr	Dr	Xp	Xp	Bl	Br	Br	Ce	Ce	Co	Fo	He	Ki	Le	Li	Li	Lu	Pa	Pl	Pl	Sk	Sk	Sk	Sm	Sp	Sp	St	Te	Th	Ut

Mature sequence

Hsa-Mir-451_5p

mirBase accession

MIMAT0001631

Sequence

0- AAACCGUUACCAUUACUGAGUU -22

Get sequence

Proposed targets

microrna.org: MIMAT0001631
TargetScanVert: hsa-miR-451a
TargetMiner: hsa-miR-451a
miRDB: MIMAT0001631