Welcome to MirGeneDB2.0 - the curated microRNA Gene Database
MirGeneDB is a database of microRNA genes that have been validated and annotated as described in "A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome".* The initial version contained 1,434 microRNA genes for human, mouse, chicken and zebrafish. Version 2.0 contains more than 8,000 genes from 34 organisms representing nearly every major metazoan group, and these microRNAs can be browsed, searched and downloaded.
New features to MirgeneDB2.0 include:
- Extensive expression data ranging from whole animal-samples to organs/tissues to cell-types based on publicly available datasets.
- Annotations of 3' non-templated uridylations, processing motifs, and of gene variants derived from alternative processing by Drosha and/or Dicer, are now provided for every miRNA.
- Updated annotations of the 3' ends for human, mouse, zebrafish and Daphnia based on publically available CAGE data.
- Comprehensive annotations of the evolutionary origin of both miRNA families (updated) and miRNA genes (new) with all orthologues and paralogues clearly identified both through name and through the heirarchy of the database. Further, the miRNA repertoires (both family and gene) are identified for all last common ancestors of the taxa included in the data base.
- All relevant fasta and annotation files (bed & gff) for all taxa are available for immediate download.
- All known false negatives are reported separately including the mature (and if known the star) read supporting the designation.
The MirGeneDB2.0 manuscript is now available on bioRxiv: "MirGeneDB2.0: the curated microRNA Gene Database"
*Bastian Fromm1,2, Diana Domanska3, Michael Hackenberg4, Anthony Mathelier5,6, Eirik Høye2, Morten Johansen7, Eivind Hovig2,3,7, Kjersti Flatmark2,8,9 & Kevin J. Peterson10
1Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-10691 Stockholm, Sweden
2Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, N-0424 Oslo, Norway
3Department of Informatics, University of Oslo, Blindern, N-0318 Oslo, Norway
4Department of Genetics, Faculty of Sciences, University of Granada, Granada, 1s8071, Spain
5Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, N-0318 Oslo, Norway
6Department of Cancer Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital Radiumhospitalet, N-0424 Oslo, Norway
7Institute for Medical Informatics,The Norwegian Radium Hospital, Oslo University Hospital, N-0424 Oslo, Norway
8Department of Gastroenterological Surgery, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, N-0424 Oslo, Norway
9Institute of Clinical Medicine, University of Oslo, Blindern, N-0318 Oslo, Norway
10Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, U.S.